Etiopathogenic, epidemiologic and clinical-therapeutic comparison of non-hodgkins lymphoma and kaposis sarcoma / Comparação etiopatogênica, epidemiológica e clinicoterapêutica de linfoma não hodgkin e sarcoma de kaposi

ABSTRACT Background: Non-Hodgkin's lymphomas (NHL) are primary neoplasms derived from lymphocytes, and Kaposi's sarcoma (SK) is a multicentric disease of viral etiology and is associated with HIV. Aim: To study the etiopathogenesis and clinical characteristics of NHL and KS, describing their mutual factors. Methods: This retrospective investigation was performed on 101 medical charts. The patients were studied according to their age, gender, and HIV-positivity, following the PRISMA guidelines. The characteristics of the tumors and comorbidities were analyzed according to their age and lymphatic metastasis. Results: The mean age of the patients ranged between 15-87 years for NHL and between 25-54 for KS, but the age of patients with NHL associated with HIV did not surpass 34 years. The ratio male: female was 1,8:1 for NHL, but only men presented KS. HIV-positivity was found in five patients with NHL and in 14 with KS. The stages of NHL were: I (21%), II (18,4%), III (26,3%), and IV (34,2%), but KS were found only at III (40%) and IV (60%) stages. The lymphatic metastases were positive in 62 patients NHL and in four with KS. HIV-positivity occurred in 60% of patients with NHL and in 50% with KS. Conclusion: The HIV seropositivity was revealed for most of patients during the NHL and SK propaedeutic and none of them present clinical manifestations of AIDS. NHL associated with HIV was found only in young patients. NHL and KS patients have similar epidemiological, clinical, and therapeutic characteristics.

RESUMO Racional: Os linfomas não Hodgkin (LNH) são neoplasias primárias derivadas de linfócitos e o sarcoma de Kaposi (SK) é doença multicêntrica de etiologia viral, ambas associadas ao HIV. Objetivo: Avaliar características clínicas dos LNH e SK, relacionando fatores etiopatogênicos mútuos. Métodos: Foram avaliados retrospectivamente 101 prontuários. Os doentes foram analisados quanto a idade, sexo e soropositividade para o HIV, de acordo com o PRISMA guidelines. Os tumores foram classificados por estadiamento, presença de linfonodos regionais invadidos e tipo celular. Resultados: A idade variou entre 15 e 87 anos para o LNH e 25 a 54 anos para o SK, mas a idade dos pacientes com LNH associado com o HIV não ultrapassou 34 anos. A proporção homem: mulher foi de 1,8:1 para o LNH, enquanto SK foi registrado apenas em homens. A soropositividade para o HIV ocorreu em cinco pacientes com LNH e 14 com SK. A invasão de linfonodos regionais foi positiva em 62 com LNH e quatro com SK. Os linfomas foram 27,9% de baixo grau, 17,4% de grau intermediário e 12,8% de alto grau. A soropositividade para HIV, foi diagnosticada durante a propedêutica do tumor em 60% dos pacientes com LNH e 50% dos com SK. Conclusão: A maioria dos pacientes portadores de HIV descobriram a soropositividade durante propedêutica para LNH e SK, sem manifestações clínicas de AIDS. Todos os pacientes com LNH associado com o HIV eram jovens. Pacientes com LNH e com SK apresentam características epidemiológicas, clínicas e terapêuticas semelhantes entre si.

Evolución de un linfoma no Hodgkin "triple expresor" en un paciente trasplantado renal con quimioterapia DA-R-EPOCH. Caso clínico / Triple expressor lymphoma in a kidney transplant patient

Patients transplanted from solid organs have an increased risk of cancer, especially lymphomas. Lymphomas correspond to 4 to 5% of malignant neoplasms in the general population and in solid organ transplant patients it reaches an incidence of 21%. The incidence of non-Hodgkin lymphomas is 10 times higher than in the non-transplanted population. We report the case of a 68-year-old man with a kidney transplant who 6 years after transplantation, developed a non-Hodgkin diffuse large cells B lymphoma with lymph node and pulmonary involvement, with markers of very poor prognosis (triple MYC expressor, BCL2 and BCL6). and its evolution with chemotherapy with DA R EPOCH.

Linfoma primario difuso de células B grandes de mucosa gingival, en paciente VIH y EBV negativos / Primary gingival diffuse large b-cell lymphoma in HIV/EBR negative patient abstract

El linfoma difuso de células B grandes (LDCBG) es el linfoma más frecuente. La presentación clínica puede ser nodal o extranodal y sus síntomas dependen de la localización tumoral; en la mayoría de los casos están asociados a algún tipo de inmunodeficiencia. Referiremos un caso de LDCBG de presentación atípica en una localización muy infrecuente. Es importante tener en cuenta estas situaciones, ya que pueden simular otros procesos patológicos, retrasando así su correcto diagnóstico y por lo tanto un adecuado tratamiento. (AU)

Diffuse large cell lymphoma B (LDCBG) is the most common type of lymphoma. It´s clinical presentation can be nodal or extranodal and it's symptoms depend where the tumor is located and whether is associated or not with an immunodeficiency disease. We present an atypical presentation of a LDCBG in a very unusual location. It´s important to consider these kind of appearance, as they can mimic other oral pathological processes, delaying their correct diagnosis and therefore an appropriate treatment. (AU)

Intususcepción ileocólica en el adulto como presentación de un linfoma no Hodgkin de intestino delgado / Ileocolic Intussusception in Adults due to Small-Bowel Non-Hodgkin's Lymphoma

La intususcepción intestinal, definida como la penetración de un segmento intestinal en otro adyacente, es una causa infrecuente de obstrucción intestinal en el adulto. El objetivo de este trabajo es presentar el caso de un paciente adulto con intususcepción ileocólica como presentación de un linfoma no Hodgkin de intestino delgado. Este paciente presenta una causa poco frecuente de intususcepción intestinal. Dada lo inespecífico de la clínica, el diagnóstico etiológico suele ser intraoperatorio, precisando resección de la lesión causante y, en el caso de nuestro paciente, quimioterapia adyuvante(AU)

Intestinal intussusception, defined as penetration of an intestinal segment into an adjacent, is a rare cause of intestinal obstruction in adults. The aim of this paper is to present the case of an adult patient with ileocolic intussusception as presenting a non-Hodgkin lymphoma of the small intestine. This patient has a rare cause of intestinal intussusception. Because of its non-specific clinical, etiologic diagnosis is usually intraoperative, requiring resection of the culprit lesion and, in the case of our patient, adjuvant chemotherapy(AU)

Enfermedad celíaca: revisión / Celiac disease: a review

La Enfermedad Celiaca (EC) tiene una prevalencia cercana al 1% de la población general y se considera que hay un número importante de pacientes asintomáticos no diagnosticados. Su presentación clínica es variable comprendiendo el clásico síndrome de malabsorción, formas menores y la EC silente. El diagnóstico serológico tiene una elevada sensibilidad y especificidad y siempre debe confirmarse con biopsia. El diagnóstico en pacientes en dieta libre de gluten incluye test de tipificación de HLA y prueba de dieta con gluten con estudio serológico e histológico posterior. El pilar del tratamiento es la dieta libre de gluten, que debe ser supervisada por un nutriólogo con experiencia. La monitorización de la terapia debe realizarse con serología. La EC mal controlada puede determinar complicaciones como linfoma y adenocarcinoma de intestino delgado. En el futuro es probable que nuevas terapias farmacológicas sean de utilidad en el manejo de la EC.

Celiac disease has a prevalence near to 1% of general population and there is an important amount of asymptomatic people not yet diagnosed. Clinical presentation includes the classical malabsorption syndrome, minor and silent celiac disease. Serologic diagnosis has an elevated sensitivity and specificity, and must be confirmed by biopsy. Diagnosis in those on gluten free diet includes HLA type and gluten challenge with posterior serologic and histologic evaluation. The core of the treatment is the gluten free diet that must be supervised by an expert nutritionist. Monitoring is with serology. Poor disease control can determine complications such as lymphoma and small bowel adenocarcinoma. In the future, it is likely that new pharmacologic therapies will be available for the management of celiac disease.

Linfoma não-Hodgkin de células T envolvendo a cavidade oral em paciente com o vírus da imunodeficiência humana positivo: relato de caso / T-cell Non-Hodgkin lymphoma of the oral cavity in human acquired virus-positive patient: case report

Linfoma não-Hodgkin (LNH) é uma das complicações oncológicas mais frequentes em portadores da síndrome da imunodeficiência adquirida (SIDA). O risco de desenvolvimento do Linfoma não-Hodgkin nos pacientes infectados pelo vírus da imunodeficiência humana (HIV) está diretamente relacionado à imunossupressão crônica,sendo particularmente mais frequentes nos paciente com baixa contagem de CD4. O objetivo deste estudo foi relatar o caso de Linfoma não-Hodgkin de células T em cavidade oral, em paciente com o vírus da imunodeficiência humana positivo, enfatizando a sua importância clínica e a necessidade do diagnóstico precoce especialmente em pacientes com SIDA. Paciente do sexo feminino, 38 anos, sabidamente HIV positivo, sem tratamento antirretroviral, apresentando tumoração extensa, vegetante, friável, de bordos irregulares, dolorosa em palato duro, acompanhada de linfoadenomegalia à direita. Realizada biópsia da lesão e estudo imuno-histoquímico com resultado de linfoma não-Hodgkin de células T. Foi iniciado tratamento específico para HIV e encaminhamento para centro onco-hematológico especializado. O caso relatado reflete rara manifestação de Linfoma não-Hodgkin em cavidade oral, em paciente com o vírus da imunodeficiência humana positivo, reforçando sua importância clínica e a necessidade do diagnóstico precoce, a fim de diminuir a morbimortalidade e melhorar seu reconhecimento clínico.

Non-Hodgkin lymphoma (NHL) is one of the most common cancer complications in patients with acquired immunodeficiency syndrome (AIDS). The risk of developing NHL in human immunodeficiency virus (HIV)-infected patients is directly related to chronic immunosuppression, and particularly more frequent in patients with low CD4 count. The aim of this study was to report the case of T-cell NHL in the oral cavity in HIV-infected patients, emphasizing its clinical importance and necessity of early diagnosis especially in patients with AIDS.Thirty-eight-year-old female patient, HIV-positive, without antiretroviral treatment, showing extensive, vegetative, friable, of ragged edges, painful tumor on hard palate, accompanied by lymphoadenomegaly on the right side. Biopsy of the lesion, and immunohistochemical study were performed with result of T-cell non-Hodgkin lymphoma. Treatment was started specifically for HIV, and patient was referred to a specialized oncohematological center. The related case reflects a rare manifestation of non-Hodgkin lymphoma in the oral cavity in HIV-positive patient, reinforcing its clinical importance and necessity of early diagnosis in order to decrease morbidity and mortality and improve its clinical recognition.

Valor pronóstico de las isoenzimas de LDH en pacientes con linforma no hodgkin / Prognostic value of LDH isoenzymes in patients with non-Hodgkin linforma

La enzima lactato deshidrogenasa (LDH) es un factor pronóstico en Linfoma No Hodgkin (LNH). El objetivo del trabajo consistió en evaluar prospectivamente el valor pronóstico de las isoenzimas de LDH en pacientes con LNH. Se estudiaron 67 pacientes de primera consulta con diagnóstico de LNH, sin tratamiento previo, VIH negativo y sin otras enfermedades, tiempo promedio de seguimiento 30 meses (rango 3-48 meses). Las muestras de suero se recolectaron previas al tratamiento. La LDH total (LDHT) e isoenzimas de LDH se determinaron respectivamente por método cinético y electroforesis de proteínas en gel de agarosa. Se procesaron muestras de 122 controles sanos para establecer los valores de referencia de las isoenzimas de LDH. 49(73%) LNH agresivos y 18(27%) LNH indolentes y según el Índice Pronóstico Internacional (IPI), 60 (90%) bajo riesgo y 7(10%) alto riesgo. Las isoenzimas LDH1, LDH2, LDH3, LDH4 y LDH5 presentaron niveles absolutos significativamente elevados en 25 (37%), 29 (43%), 32 (48%), 20 (39%) y 11 (16%) de los casos respectivamente (p<0,0001). La actividad porcentual de LDH4 en los pacientes con LNH agresivos fue significativamente superior respecto al grupo de LNH indolentes (p=0,01). En el análisis univariado, valores absolutos elevados de LDH1 se asociaron significativamente con una sobrevida global disminuida (p=0,0064) en el grupo total de pacientes. LDH1 conservó su valor pronóstico aún en el grupo de pacientes con valores normales de LDHT (p=0,04). En pacientes con LNH agresivos, valores elevados de LDHT e IPI alto riesgo se asociaron significativamente con una menor sobrevida global (p<0,05). En el análisis multivariado la LDHT e IPI resultaron factores pronósticos independientes de la sobrevida. Alteraciones específicas del patrón de isoenzimas de LDH sugieren la relación de LDH4 con la biología del tumor y su actividad proliferativa en LNH agresivos y el valor pronóstico de LDH1 como factor adverso de la sobrevida en el análisis univariado.

Lactate dehydrogenase (LDH) is a prognostic factor in non-Hodgkin lymphoma (NHL). Our objective was to evaluate prospectively the prognostic value of LDH isoenzymes in patients with NHL. We studied 67 newly diagnosed NHL patients, previously untreated, HIV-negative and free from other disease, median follow-up of 30 month (range 3-48 month). Before starting treatment serum samples were collected for the determination of total LDH (LDHT) and LDH isoenzymes that were respectively assayed by kinetic method and protein electrophoresis in agarose gel. In order to set reference values of LDH isoenzymes samples from122 healthy controls were processed. Results: 49(73%) of the patients were aggressive NHL and 18(27%) indolent NHL and according to the International Prognostic Index (IPI), 60(90 %) low risk and 7(10%) high risk. High absolute values of LDH1, LDH2, LDH3, LDH4 and LDH5 isoenzymes were significantly elevated in 25 (37%), 29 (43%), 32 (48%), 20 (39%) and 11 (16%) of cases respectively (p<0,0001). The percentage value of LDH4 activity in aggressive NHL patients was significantly higher compared to indolent NHL group (p=0,01). In univariate analysis increased LDH1 absolute values were significantly associated with decreased overall survival in the total group of patients (p = 0.0064). LDH1 remained a prognostic factor for survival even when considering the group of patients with normal serum LDHT values (p = 0.04). In patients with aggressive NHL increased values of LDHT and high risk IPI were significantly associated with decreased overall survival (p<0.05). In a multivariate analysis LDHT and IPI score were independent prognostic factor for survival.

Manejo actual de los linfomas / Current concepts: management of lymphomas

Lymphomas constitute a heterogeneous group of neoplastic diseases of the lymphatic system. Between all the varieties of malignancies, lymphomas show problems and special opportunities for the diagnosis and detections. The existence of numerous histologic subtypes and the similarity of malignant lymphocytes with the normal lymphocytes in their distinct stages of differentiation and activation, had led to the development of sophisticated diagnosti methods to assist the morphology in the recognition of them. Special considerations are made about the non-Hodgkin's lymphomas and the Epstein-Barr virus. The author also details the classification, the treatment and the epidemiology.

Linfoma no Hodgkin en pacientes con SIDA: una reflexión necesaria / Non-Hodking lymphoma in AIDS patients: a necessary reflection

El linfoma no Hodgkin constituye una de las 3 afecciones malignas marcadoras de SIDA reconocidas actualmente. Tanto en Cuba, como en el resto del mundo, en la última década se ha observado su incremento en pacientes infectados por el virus de la inmunodeficiencia humana (VIH). Por las razones anteriormente planteadas, se realizó una revisión bibliográfica actualizada del tema en revistas de alto impacto internacional, para describir los principales elementos de esta enfermedad (clasificación, epidemiología, evolución y tratamiento) y brindar, de esta forma, una guía para el trabajo de los profesionales de la atención primaria en el seguimiento de estos pacientes en la comunidad.

Primary testicular non-Hodgkin's lymphoma: a review article

Primary testicular non-Hodgkin's lymphoma was first described as a clinical entity in 1866. It is a rare disease and accounts for 1 percent of all non-Hodgkin's lymphoma, 2 percent of all extranodal lymphomas and 5 percent of all testicular neoplasms. It is the most common testicular tumor in males between sixty and eighty years of age. Testicular non-Hodgkin's lymphoma is unique in its high incidence of bilateral involvement (8-38 percent), and it is also the most common bilateral testicular tumor. Testicular non-Hodgkin's lymphoma has a predilection for spreading to non-contiguous extranodal sites, especially the central nervous system. Advanced-stage disease is usually managed with doxorubicin-based chemotherapy. For early-stage disease, opinion is divided regarding systemic chemotherapy following orchidectomy. The high incidence of spreading, especially to the central nervous system, leads to advocacy of the use of central nervous system prophylaxis with intrathecal chemotherapy. Prospective multicenter trials incorporating a large number of patients may lead to better guidelines for optimal management of this subtype of non-Hodgkin's lymphoma.

O linfoma primário do testículo (LPT) foi descrito como uma entidade clínica pela primeira vez em 1866. É uma doença rara e corresponde a 1 por cento de todos os linfomas não-Hodgkin, 2 por cento de todos os linfomas extranodais e 5 por cento de todos as neoplasias testiculares. É o tumor testicular mais comum em homens entre 60 e 80 anos de idade. LPT é único em sua elevada incidência de envolvimento bilateral (8-38 por cento), sendo o tumor testicular bilateral mais comum. Tem uma predileção por disseminação para regiões extranodais não-contíguas, especialmente para o sistema nervoso central (SNC). Estágios avançados da doença são usualmente tratados com quimioterapia à base de doxorubicina. Para os estágios mais precoces, as opiniões são divergentes quanto à quimioterapia associada à orquiectomia. A alta prevalência de disseminação, especialmente para o SNC, sugere o uso de quimioterapia intratecal como profilaxia. Estudos prospectivos multicêntricos incluindo um grande número de pacientes poderiam resolver a questão com relação ao manejo deste subtipo de linfoma não-Hodgkin.

Linfoma No Hodgkin (LNH) asociado a SIDA en la cavidad bucal: reporte de caso clínico / AIDS-related Non-Hodgkin lymphoma in the oral cavity: report of a clinical case

El riesgo de Linfoma No Hodgkin (LNH) en las personas con infección por el Virus de Inmunodeficiencia Humana (VIH) es cien veces mayor respecto al resto de la población. La incidencia de estas neoplasias en hombres jóvenes en la década de los 80 aumentó veinte veces producto de la infección por el VIH. No obstante, en los últimos años, el Síndrome de Inmunodeficiencia Adquirida (SIDA) es factor de riesgo condicionante de una discreta proporción de los casos de LNH. Estos linfomas suelen presentarse en su mayoría de células B con histología de alto grado, principalmente del subtipo difuso de células grandes, con compromiso extraganglionar frecuente y principalmente en el sistema nervioso central (SNC). En general, el entorno clínico y la respuesta al tratamiento de los pacientes con linfoma relacionado con el SIDA son muy diferentes a los de los pacientes seronegativos con linfomas. El individuo con linfoma agresivo que presenta infección por VIH se presenta generalmente con enfermedad en etapa avanzada que suele ser extraganglionar. Su curso clínico es más agresivo, la enfermedad es más extensa y menos sensible a la quimioterapia. Presentamos un caso clínico de Linfoma No Hodgkin en cavidad bucal en un paciente con las características antes mencionadas que acudió al Centro de Atención a Pacientes con Enfermedades Infectoectocontagiosas "Elsa La Corte" - CAPEI de la Facultad de Odontología de la Universidad Central de Venezuela, referido por el Centro de Hematooncología de la misma universidad, del cual destacamos el manejo interdisciplinario médico-odontológico del mismo.

Non-Hodgkin's Lymphoma's risk (NHL) in the persons with infection for the Human of Immunodeficiency Virus (HIV) is hundred times major with regard to the rest of the population. The incidence of these neoplasms in young men, in the decade of the 80 increased twenty times product of the infection for the HIV. Nevertheless, in the last years, the Acquired Immunodeficiency Syndrome (AIDS) is a cause of a discreet proportion of NHL's cases. These lymphomas are in the habit of appearing in the main of cells B with histology of high degree, principally of the diffuse subtype of big cells, with extranodal frequent compromise and principally in the nervous central system (NCS). In general, the clinical environment and the response to the treatment of the patients with lymphoma related to the AIDS are very different from those of the HIV_negative patient with lymphomas. The individual with aggressive lymphoma that presents infection for HIV appears generally with disease in advanced stage that is in the habit of being extranodal. The clinical course is more aggressive, the disease is more extensive and less sensitive to the chemotherapy.We present Non-Hodgkin's Lymphoma's clinical case in oral cavity in a patient with the characteristics before mentioned that came to the Center of Attention to Patients with Infectious and Contagious Diseases "Dra. Elsa La Corte" of the Faculty of Odontolgy of the Central University of Venezuela, refered by Hematooncology's Center of the same university.

Primary non Hodgkin's lymphomas of gastriointestinal tract a clinico pathological study

This study aims to retrospectively review the pattern of patients with various gastro-intestinal lymphomas seen in King Abdul Aziz Hospital, Jeddah, Saudi Arabia from June 1990 to June 2002 with a view to determine and analyze various clinical and pathological aspects of this disease. All cases of Primary non-Hodgkin's lymphoma of gastro-intestinal tract received and diagnosed in Histopathology department of King Abdul Aziz Hospital, Jeddah, between June 1990 and June 2002 were retrospectively reviewed and the data was analyzed to determine age gender, ethnicity, clinical presentation, anatomical localization, histological type and Helicobacter pylori status. A total of 47 patients were retrieved for this study, with 85.10% being Saudi nationals. The male to female ratio was 1 : 0.74%. The mean age was 52.44 years. The peak age of onset was in the 6th decade. About 45% of our patients had gastric lymphoma, whereas 20.53% had small bowel lymphoma. Among the total number of patients, 46.81% men had MALT type lymphomas. Helicobacter pylori were positive in all patients with gastric lymphoma. Gastrointestinal lymphomas are frequently seen in patients in Saudi Arabia, with MALT gastric lymphoma being the commonest tumour. The strong association between H. Pylori and gastric lymphoma as an important aetiological factor is emphasized

Massa torácica em paciente com Sida (Aids) / Thorax mass in Sida patient

Os autores apresentam um relato de caso de massa torácica em paciente HIV+, com contagem de células CD4 > 200/mm³. O estudo histopatológico e imuno-histoquímico da lesão mostrou tratar-se de linfoma do tipo Burkitt, tipo freqüente de linfoma não-Hodgkin em pacientes com Sida, devendo-se fazer diferenciação com o linfoma difuso de grandes células B, também comum em imunocomprometidos, já que o tratamento quimioterápico de escolha é diferente nos dois tipos

Manifestações bucais associadas à Síndrome da Imunodeficiência Adquirida / Oral manifestations associated to Acquired Immunodeficiency Syndrome

Muitas lesões bucais têm sido relatadas em pacientes com Síndrome da Imunodeficiência Adquirida (Sida), desde seus primeiros ralatos publicados em 1981, em homens homossexuais moradores da Califórnia, EUA. A prevalência de lesões bucais está mudando com os avanços na terapia, como o exemplo da HAART. Os autores realizam revisão da literatura sobre as manifestações bucais que podem acometer pacientes com Sida, bem como os tratamentos mais indicados destas lesões

Head and neck manifestations of HIV infection: a preliminary study.

The study deals with evaluation of the head and neck manifestations of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). It is a preliminary, prospective study, conducted in the department of ENT and microbiology, Regional Institute of Medical Sciences, Imphal, Manipur. The clinical presentations for HIV infection and AIDS with head and neck involvement are shown in this paper. Forty patients with HIV infection and various head and neck manifestations are included in this study The median age of diagnosis was 33 years with male to female ratio of 3.4: 1. The predominant mode of transmission of HIV infection among the patients of this series was found to be intravenous drug use (IDU) in 65% of cases. Rhinosinusitis was found to be the most common presenting feature constituting 27.5% of the cases followed by oral candidiasis in 22.5% of the cases. After consideration and observation of all the facts and findings, this study concludes and proposes that it will be well for all clinicians, including otolaryngologists especially, to bear a high level of suspicion for HIV infections in their day to day practice.

Ankylosing spondylitis associated with non-Hodgkin's lymphoma.

Malignancies have rarely been reported in patients with ankylosing spondylitis either as a complication of therapy or de novo. Here we report a 37 years male with ankylosing spondylitis who developed non-Hodgkin's lymphoma during the course of his illness.

Linfomas näo Hodgkin: atualizaçäo e aspectos controversos / Non-Hodgkin's lymphomas: actualization and controversial aspects

Os autores apresentam uma breve revisäo sobre os linfomas näo Hodgkin, destacando aas principais características quanto à clínica, patologia, diagnóstico e terapêutica dos mesmos. Além desse aspecto, centram, principalmente, seus tópicos de discussäo nos aspectos relevantes sobre as diversas classificaçöes até entäo propostas aos linfomas e já descritas na literatura mundial.

Epstein-Barr virus induced non-Hodgkin's lymphoma as a presenting manifestation of acquired immune deficiency syndrome.

A 30 year old, human immunodeficiency virus (HIV) positive patient presented with fever and intra-abdominal lymphadenopathy. Cytology smears from the nodes showed a high grade Non-Hodgkin's lymphoma (NHL) which was B cell in origin. NHL was the acquired immune deficiency syndrome (AIDS) defining disease in this patient. Polymerase chain reaction (PCR) studies on tumour tissue showed presence of Epstein Barr Virus.